Histological Evaluation of Cisplatin-Induced Gonadotoxicity against Murine Visceral Leishmaniasis

Cisplatin had shown anti-leishmanial effect both in vitro and in vivo against murine visceral leishmaniasis. The present study was designed to evaluate the effect of cisplatin on gonads of Leishmania donovani infected BALB/c mice. In drug treated animals, mild reduced spermatogenesis was observed but when antioxidants were supplemented along with cisplatin, the morphological characteristics of testes were comparable to those in control groups. Moreover, the ovary was also found to be normal in the oestrus phase with development of corpus luteum. The above findings showed that damage caused by cisplatin to gonads was ameliorated by administration of antioxidants.